Talking South Park Hearts can be a little tricky to pull off, especially if you're the writer. It's hard enough just trying to make a decent story, let alone a series of episodes and a movie. That doesn't mean the task isn't worth it, though. If done right it can be a really fun and enjoyable project. So what exactly should you do?
The key is to talk about the relationships you have with your characters. I'm sure you'll need to tell us how important Cartman is to your character. Who else has strong ties to the main character? Who is not on the main character's radar at all? How important is Stan to Randy? How important is Kyle to Jimmy?
Use those particular relationships as stepping stones for more specifics. You can give your character descriptions for each relationship and then describe each person individually. It might help if you explain what your character thinks about the relationship, if you can. Have your character tell you what he thinks or feels about the situation. It also makes it easier to write if you actually say it out loud. Just keep in mind that the more details you provide for your character's thoughts and feelings, the more you will be able to build strong emotional ties between them.